Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson’s disease
Identifieur interne : 000492 ( Main/Exploration ); précédent : 000491; suivant : 000493Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson’s disease
Auteurs : Eun-Young Lee [États-Unis] ; Paul J. Eslinger [États-Unis] ; Guangwei Du [États-Unis] ; Lan Kong [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Xuemei Huang [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Olfaction Disorders.
- pathology : Atrophy, Cerebral Cortex.
- Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index, Statistics as Topic.
Abstract
Olfactory dysfunction is often associated with Parkinson’s disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.
High-resolution T1-weighted brain magnetic resonance images were acquired from 40 PD without dementia and 40 matched Controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry (VBM).
Compared to Controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.
Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.
Url:
DOI: 10.1002/mds.25829
PubMed: 24482154
PubMed Central: 4116478
Affiliations:
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Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Kinesiology, Pennsylvania State University-Milton S. 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Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Eslinger, Paul J" sort="Eslinger, Paul J" uniqKey="Eslinger P" first="Paul J." last="Eslinger">Paul J. Eslinger</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Du, Guangwei" sort="Du, Guangwei" uniqKey="Du G" first="Guangwei" last="Du">Guangwei Du</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Atrophy (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Olfaction Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Olfactory dysfunction is often associated with Parkinson’s disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.</p></sec><sec id="S2"><title>Methods</title><p id="P2">High-resolution T1-weighted brain magnetic resonance images were acquired from 40 PD without dementia and 40 matched Controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry (VBM).</p></sec><sec id="S3"><title>Results</title><p id="P3">Compared to Controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lee, Eun Young" sort="Lee, Eun Young" uniqKey="Lee E" first="Eun-Young" last="Lee">Eun-Young Lee</name></region><name sortKey="Du, Guangwei" sort="Du, Guangwei" uniqKey="Du G" first="Guangwei" last="Du">Guangwei Du</name><name sortKey="Eslinger, Paul J" sort="Eslinger, Paul J" uniqKey="Eslinger P" first="Paul J." last="Eslinger">Paul J. Eslinger</name><name sortKey="Eslinger, Paul J" sort="Eslinger, Paul J" uniqKey="Eslinger P" first="Paul J." last="Eslinger">Paul J. Eslinger</name><name sortKey="Eslinger, Paul J" sort="Eslinger, Paul J" uniqKey="Eslinger P" first="Paul J." last="Eslinger">Paul J. Eslinger</name><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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